NAD⁺ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every living cell, playing a central role in energy production, DNA repair, and cellular signaling. It is essential for metabolic function, acting as an electron carrier during ATP synthesis and serving as a substrate for sirtuins and PARPs—enzymes tied to aging, genomic stability, and stress response.
NAD⁺ levels decline with age, which has been linked to mitochondrial dysfunction, insulin resistance, and cognitive decline. As a result, NAD⁺ is being widely studied in models of aging, neurodegeneration, metabolic disorders, and cardiovascular health. Research into NAD⁺ supplementation—either directly or via precursors like NMN and NR—has shown promising effects on cellular health and resilience.
$119.97
Nicotinamide adenine dinucleotide (NAD⁺) is a vital redox coenzyme present in all living cells. It plays a central role in cellular respiration, energy production, DNA repair, and intracellular signaling. In preclinical research, NAD⁺ has been widely studied for its role in age-related physiological decline, mitochondrial efficiency, and oxidative stress regulation. Its importance in metabolic homeostasis makes it a frequent target in laboratory studies involving cell health, senescence, and longevity pathways.
NAD⁺ acts as a cofactor in redox reactions by cycling between oxidized (NAD⁺) and reduced (NADH) states. It is essential in key metabolic pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. Additionally, NAD⁺ serves as a substrate for several signaling enzymes, including sirtuins and PARPs, which are involved in gene regulation, stress resistance, and DNA repair. In animal and cell models, manipulating NAD⁺ levels has demonstrated effects on mitochondrial biogenesis, ATP production, and inflammatory cytokine signaling.
Preclinical studies have explored NAD⁺ in a wide array of biological systems, including neurodegeneration models, metabolic syndrome, circadian rhythm regulation, and skeletal muscle function. Rodent and in vitro models have been used to evaluate NAD⁺ supplementation and NAD⁺ precursors in contexts related to oxidative damage, mitochondrial dysfunction, and lifespan extension. NAD⁺ has also been studied in the context of metabolic reprogramming and redox balance under various forms of cellular stress.
Ongoing research has examined long-term changes in NAD⁺ levels with age and their impact on energy metabolism, autophagy, and protein acetylation patterns in non-human models. Investigations into sirtuin activation and mitochondrial resilience under caloric restriction or toxin exposure often include NAD⁺ as a key regulatory component. Its systemic role in maintaining metabolic flexibility continues to make NAD⁺ an essential molecule in aging and cellular repair-related experimental studies.
NAD⁺ has shown high tolerability in animal research models and in vitro applications, with minimal adverse effects under controlled laboratory dosing. This compound is not approved for human or veterinary use. NAD⁺ sold here is strictly for laboratory research purposes only and must not be used for injection, ingestion, or therapeutic application. All use must comply with local research laws and institutional guidelines.
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