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GHK-CU

GHK-Cu is a naturally occurring copper peptide that researchers have studied extensively for its regenerative, anti-inflammatory, and gene-modulating properties. This tripeptide, composed of glycine, histidine, and lysine bound to copper(II), plays an essential role in wound healing, tissue remodeling, and cellular repair.

GHK-Cu activates genes that promote collagen production, angiogenesis, and antioxidant defense, while suppressing pathways tied to inflammation and tissue degradation in experimental models.

Researchers use it to explore skin regeneration, scar reduction, and hair follicle support, often reporting improvements in elasticity, firmness, and dermal structure. GHK-Cu also shows promise in antimicrobial and neuroprotective applications. Because natural GHK-Cu levels decline with age, the compound continues to draw interest in anti-aging and longevity studies.

Peptides will arrive in a lyophilized (powder) form for maximum stability

$69.97

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🧬 Overview

GHK-Cu (glycyl-L-histidyl-L-lysine: copper(II)) is a naturally occurring copper-binding tripeptide found in human plasma and extracellular fluid. First identified in the 1970s, GHK-Cu has since been widely studied for its potential to support cellular regeneration, tissue remodeling, and antioxidant activity in controlled laboratory environments. Research has focused on its activity in dermal, epithelial, and connective tissue systems, particularly in models simulating wound healing, aging, and oxidative stress.

⚙️ Mechanism of Action

GHK-Cu functions as a carrier of divalent copper ions, influencing numerous biological processes at the cellular level. In vitro and animal studies suggest the peptide may regulate gene expression linked to tissue repair, collagen synthesis, and antioxidant enzyme activity. Additionally, GHK-Cu has been observed to modulate levels of transforming growth factor-beta (TGF-β), metalloproteinases, and fibroblast activation—making it a valuable compound in experimental dermatological and tissue engineering research.

🧪 Key Research Focus Areas

GHK-Cu is commonly studied in the context of dermal regeneration, wound closure, and extracellular matrix remodeling. Laboratory investigations have also explored its impact on oxidative stress, anti-inflammatory pathways, and neuroprotective environments. Additional models have evaluated its influence on hair follicle signaling, angiogenesis, and integrin expression under laboratory conditions. The peptide’s ability to complex with copper ions provides a unique model for studying metal-dependent signaling and enzymatic regulation.

⏳ Extended Research Interest

Ongoing preclinical research has investigated the role of GHK-Cu in skin aging models, including those involving UV exposure, glycation, and structural protein degradation. Its copper-binding functionality has also made it of interest in neuroscience, immune modulation, and chronic inflammation models. Some rodent studies have explored its long-term impact on tissue resilience and repair mechanisms in chemically-induced damage models.

🧫 Safety & Tolerability (Research Use Only)

GHK-Cu has demonstrated a favorable safety profile in various preclinical models and is generally considered well tolerated in standard research concentrations. This product is not approved for human or veterinary use and is intended exclusively for in vitro and laboratory-based scientific research. All research must adhere to legal and institutional compliance standards governing synthetic peptides and metal-binding compounds.

🧬 Sequencing & Structural Data

  • Sequence: Gly-His-Lys·Cu(II)
  • Molecular Formula: C14H24N6O4Cu
  • Molecular Weight: 403.9 g/mol
  • CAS Number: 89030-95-5
  • PubChem CID: 16219428
  • Synonyms: Copper GHK, GHK-Cu Tripeptide, Copper tripeptide-1

📚 References

  1. https://pubmed.ncbi.nlm.nih.gov/16029679/
  2. https://pubmed.ncbi.nlm.nih.gov/18637708/
  3. https://pubmed.ncbi.nlm.nih.gov/20404546/
  4. https://pubmed.ncbi.nlm.nih.gov/24844734/
  5. https://pubmed.ncbi.nlm.nih.gov/16678116/

⚠️ Legal Disclaimer

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro laboratory research only. In-vitro studies (Latin: “in glass”) are performed outside of living organisms. These products are not medicines or drugs, and they have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. Under no circumstances should these products be introduced into the human or animal body, whether by injection, ingestion, topical application, or any other route. Bodily introduction is strictly prohibited by law.

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