Retatrutide

🧬 Retatrutide – Triple Hormone Receptor Agonist for Metabolic Research

🔍 Overview

Retatrutide (LY3437943) is a synthetic peptide designed as a triple agonist for the GLP-1, GIP, and glucagon receptors. This unique mechanism positions Retatrutide as a valuable compound in metabolic research, particularly in studies related to obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD).

⚠️ For Research Use Only – Not for human consumption or therapeutic applications.

⚙️ Mechanism of Action

Retatrutide simultaneously activates three key receptors involved in metabolic regulation:

• 🧬 GLP-1 Receptor (Glucagon-Like Peptide-1): Enhances insulin secretion, suppresses glucagon release, and slows gastric emptying.

• 🧪 GIP Receptor (Glucose-Dependent Insulinotropic Polypeptide): Stimulates insulin release and may improve insulin sensitivity.

• 🔥 Glucagon Receptor: Increases energy expenditure and may aid in weight management.

This triagonist approach offers a synergistic effect, potentially leading to superior outcomes in metabolic research compared to single or dual agonist compounds.

📊 Research Highlights

• Weight Reduction: Studies report up to 24% weight loss over 48 weeks in research participants.

• Glycemic Control: Notable improvements in HbA1c and glucose tolerance markers.

• Liver Health: Reduced liver fat content in early studies targeting NAFLD.

🧪 Additional Research Areas

• 🫀 Cardiovascular health and lipid profile support

• 🧬 Anti-inflammatory activity across metabolic tissues

• ⚡ Enhanced basal metabolic rate and energy expenditure

✅ Safety & Observations

Retatrutide has been generally well-tolerated in preclinical and early human studies. Mild GI symptoms such as nausea and diarrhea have been observed, typically decreasing over time.

Note: Research use only. Not approved for human or veterinary applications.

🧾 Peptide Details & Structure

• Amino Acid Sequence: Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-MeLeu-Leu-Asp-Lys-Lys(AEEA-γ-Glu-C20 diacid)-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂

• Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈

• Molecular Weight: 4731.33 g/mol

• CAS Number: 2381089-83-2

• Synonyms: LY3437943

🧬 Molecular Structure Illustration

📚 References

• 📉 Obesity Phase 2 Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972

• 🧪 Metabolic Disorders Review: https://www.nature.com/articles/s41591-024-03018-2

• 🧬 Triple Receptor Structural Insights: https://www.nature.com/articles/s41421-024-00700-0

• 🔬 Mechanism of Action: https://synapse.patsnap.com/article/what-is-the-mechanism-of-action-of-retatrutide

• 📖 Wikipedia Entry: https://en.wikipedia.org/wiki/Retatrutide