TB-500 is a synthetic peptide modeled after a naturally occurring fragment of Thymosin Beta-4, a protein involved in cell migration and tissue regeneration. It is widely studied in preclinical settings for its ability to accelerate wound healing, reduce inflammation, and promote muscular and connective tissue repair.
TB-500’s mechanism centers on its regulation of actin, a protein critical to cell structure and movement. By enhancing actin polymerization, it supports the rapid mobilization of cells such as fibroblasts and endothelial cells to injury sites.
Researchers have explored TB-500 for use in models of tendonitis, muscle tears, corneal wounds, and even cardiac injury. Its potential for broad applications in regenerative biology makes it a highly versatile compound for laboratory investigation.
$79.97
TB-500 is a synthetic peptide fragment modeled after thymosin beta-4 (Tβ4), a naturally occurring protein found in various mammalian tissues. TB-500 has been studied extensively in preclinical research for its potential to support cellular migration, cytoskeletal organization, and tissue regeneration. Due to its high binding affinity for actin, TB-500 is frequently utilized in animal models examining wound repair, inflammation resolution, and angiogenesis.
TB-500 functions by modulating actin polymerization and promoting cellular motility in tissue repair environments. Research indicates it may influence angiogenesis, fibroblast recruitment, and inflammatory signaling through indirect growth factor interaction. In rodent models, TB-500 has been observed to play a role in the upregulation of vascular endothelial growth factor (VEGF) and modulation of extracellular matrix proteins such as laminin and fibronectin, contributing to accelerated wound closure and tissue remodeling.
Preclinical research has examined TB-500 in the context of soft tissue repair, including tendon, ligament, muscle, and epithelial tissue regeneration. Studies have explored its effects on myocardial tissue following ischemic damage, corneal wound closure, and dermal healing. In vitro models have also been used to investigate its effects on keratinocyte migration, cell adhesion, and angiogenic signaling under oxidative and mechanical stress conditions.
Chronic rodent trials have studied TB-500 for its potential in reducing fibrotic development, improving capillary density, and enhancing tissue elasticity following trauma or inflammation. Researchers have explored its impact on immune modulation, mitochondrial dynamics, and growth factor receptor sensitivity. TB-500’s unique sequence and structure allow it to act systemically in preclinical models, making it a valuable tool in studies of systemic injury recovery and organ-specific regeneration.
TB-500 has shown a high tolerability profile in rodent models, with no significant toxicity reported at standard research dosages. It is not approved for human or veterinary use. This product is provided strictly for in vitro, laboratory, and non-human scientific research. All experimental use must adhere to institutional safety protocols and national research guidelines.
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